Evaluation of contribution of cardiac sympathetic innervation to the development of essential hypertension

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dc.contributor.advisor Birren, Susan
dc.contributor.author Fu, Wenqi
dc.date.accessioned 2020-05-26T16:27:14Z
dc.date.available 2020-05-26T16:27:14Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/10192/37536
dc.description.abstract Essential hypertension or primary hypertension is defined as manifestation of high blood pressure without secondary reasons, which might be partially related to cardiac sympathetic hyperinnervation. Here, I present evidence that early chemical sympathectomy can reverse the development of essential hypertension in adult spontaneously hypertensive rats (SHR). Morphologically, in immunohistochemically stained hearts I observed and quantified changes in cardiac sympathetic fiber density of the left ventricle, and changes in cellular density in developing superior cervical ganglion (SCG). Physiologically, I measured the blood pressure using a non-invasive tail-cuff method and assayed the heart/ body weight ratio. I found that neonatal sympathectomy induced by 6-hydroxydopamine (6-OHDA) diminished cardiac sympathetic innervation and reduced blood pressure of 12-week-old SHR. This indicates existing bonds between cardiac sympathetic hyperinnervation and promoted development of hypertension. Taken together, this study provides evidence that early neonatal intervention directed towards modulation of sympathetic cardiac innervation can influence a course of essential hypertension development.
dc.format.mimetype application/pdf
dc.language English
dc.language.iso eng
dc.publisher Brandeis University
dc.relation.ispartofseries Brandeis University Theses and Dissertations
dc.rights Copyright by Wenqi Fu 2020
dc.subject sympathetic nervous system
dc.subject cardiac innervation
dc.subject hypertension
dc.title Evaluation of contribution of cardiac sympathetic innervation to the development of essential hypertension
dc.type Thesis
dc.contributor.department Department of Biology
dc.degree.name MS
dc.degree.level Masters
dc.degree.discipline Biology
dc.degree.grantor Brandeis University, Graduate School of Arts and Sciences
dc.description.esploro 2


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