Precise temperature compensation of phase in a rhythmic motor pattern.

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Show simple item record Tang, Lamont S Goeritz, Marie L Caplan, Jonathan S Taylor, Adam L Fisek, Mehmet Marder, Eve 2019-01-29T18:18:33Z 2019-01-29T18:18:33Z 2010
dc.identifier.issn 1544-9173
dc.identifier.issn 1545-7885
dc.description.abstract Most animal species are cold-blooded, and their neuronal circuits must maintain function despite environmental temperature fluctuations. The central pattern generating circuits that produce rhythmic motor patterns depend on the orderly activation of circuit neurons. We describe the effects of temperature on the pyloric rhythm of the stomatogastric ganglion of the crab, Cancer borealis. The pyloric rhythm is a triphasic motor pattern in which the Pyloric Dilator (PD), Lateral Pyloric (LP), and Pyloric (PY) neurons fire in a repeating sequence. While the frequency of the pyloric rhythm increased about 4-fold (Q(10) approximately 2.3) as the temperature was shifted from 7 degrees C to 23 degrees C, the phase relationships of the PD, LP, and PY neurons showed almost perfect temperature compensation. The Q(10)'s of the input conductance, synaptic currents, transient outward current (I(A)), and the hyperpolarization-activated inward current (I(h)), all of which help determine the phase of LP neuron activity, ranged from 1.8 to 4. We studied the effects of temperature in >1,000 computational models (with different sets of maximal conductances) of a bursting neuron and the LP neuron. Many bursting models failed to monotonically increase in frequency as temperature increased. Temperature compensation of LP neuron phase was facilitated when model neurons' currents had Q(10)'s close to 2. Together, these data indicate that although diverse sets of maximal conductances may be found in identified neurons across animals, there may be strong evolutionary pressure to restrict the Q(10)'s of the processes that contribute to temperature compensation of neuronal circuits.
dc.format.extent 1 file
dc.language English
dc.language.iso eng
dc.publisher Public Library of Science
dc.rights Creative Commons Attribution 4.0 International License
dc.subject Animals
dc.subject Brachyura
dc.subject Ganglia, Invertebrate
dc.subject Motor Activity
dc.subject Motor Neurons
dc.subject Periodicity
dc.subject Pylorus
dc.subject Synaptic Transmission
dc.subject Temperature
dc.title Precise temperature compensation of phase in a rhythmic motor pattern.
dc.type Article
dc.contributor.department Department of Biology
dc.relation.journal PLoS Biology
dc.identifier.pmid 20824168
dc.identifier.pmcid PMC2930868
dc.description.esploro yes

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