A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans

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dc.contributor.author Neal, Scott J.
dc.contributor.author Park, JiSoo
dc.contributor.author DiTirro, Danielle
dc.contributor.author Yoon, Jason
dc.contributor.author Shibuya, Mayumi
dc.contributor.author Choi, Woochan
dc.contributor.author Schroeder, Frank C.
dc.contributor.author Butcher, Rebecca A.
dc.contributor.author Kyuhyung, Kim
dc.contributor.author Sengupta, Piali
dc.date.accessioned 2017-12-05T21:36:07Z
dc.date.available 2017-12-05T21:36:07Z
dc.date.issued 2016-03-10
dc.identifier.citation G3: Genes, Genomes, Genetics May 1, 2016 vol. 6 no. 5 1475-1487
dc.identifier.issn 2160-1836
dc.identifier.uri http://hdl.handle.net/10192/35035
dc.description Published version can be found on G3's site: http://www.g3journal.org/content/6/5/1475
dc.description.abstract Animals must constantly assess their surroundings and integrate sensory cues to make appropriate behavioral and developmental decisions. Pheromones produced by conspecific individuals provide critical information regarding environmental conditions. Ascaroside pheromone concentration and composition are instructive in the decision of Caenorhabditis elegans to either develop into a reproductive adult or enter into the stress-resistant alternate dauer developmental stage. Pheromones are sensed by a small set of sensory neurons, and integrated with additional environmental cues, to regulate neuroendocrine signaling and dauer formation. To identify molecules required for pheromone-induced dauer formation, we performed an unbiased forward genetic screen and identified phd (pheromone response-defective dauer) mutants. Here, we describe new roles in dauer formation for previously identified neuronal molecules such as the WD40 domain protein QUI-1 and MACO-1 Macoilin, report new roles for nociceptive neurons in modulating pheromone-induced dauer formation, and identify tau tubulin kinases as new genes involved in dauer formation. Thus, phd mutants define loci required for the detection, transmission, or integration of pheromone signals in the regulation of dauer formation.
dc.description.sponsorship Funded by NIH grant 37 GM56223, P.S., NSF grant IOS 1256488 P.S., the Human Frontiers Science Program RGY0042/2010, P.S. and R.A.B., the Ellison Medical Foundation AG-NS-0963-12, R.A.B., in addition to the Daegu Gyeongbuk Institute of Science and Technology Research and Development Program of the Ministry of Science, an Information and Communication Technology (ICT) and Future Planning grant 15-BD-06, and the National Research Foundation of Korea NRF-2015R1D1A1A09061430.
dc.language English
dc.language.iso eng
dc.publisher Genetics Society of America
dc.rights Copyright by the authors 2016
dc.subject C. Elegans
dc.subject Dauer
dc.subject Pheromone
dc.subject Che-12
dc.subject Maco-1
dc.subject Qui-1
dc.subject TTBK
dc.title A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans
dc.type Article
dc.identifier.doi https://doi.org/10.1534/g3.115.026450

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