The Active Circuit Involved in Murine Taste Learning

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dc.contributor.advisor Nelson, Sacha Ali Marandi Ghoddousi, Ramin 2017-02-01T14:52:34Z 2017-02-01T14:52:34Z 2017
dc.description.abstract There are many different components involved in the formation of a memory. Research has shown that mammalian learning is a complex system that requires the recruitment of multiple brain regions and cell types. This active network then works together to bring together the multiple components of a particular memory. It is evolutionarily advantageous for an animal to be able to associate the taste of a toxin with its negative symptoms. Many animals, in particular mammals, have an ability to learn to avoid foods that are toxic on a trial and error basis. We can elicit this behavior in a controlled fashion in lab animals and study the anatomy and biochemistry involved. Conditioned Taste Aversion (CTA) is a robust form of one-trial taste learning that dates back to the 1960’s.(Garcia et al., 1967) During CTA an aversion to a novel taste is created by pairing the taste with a toxic compound. As part of a larger effort to study the genetic, cell type specific, and network changes involved in gustatory memory formation we are tracing connections of neurons activated during CTA. During gustatory learning, neurons in many different brain regions are activated and can be visualized through their expression of immediate early genes like FOS. These regions include the Gustatory Cortex (GC), and substructures of the Amygdala: The Central Amygdala (CA) and the Basolateral Amygdala (BLA). (Yamamoto et al., 2007) Increased functional interactions between these regions has been shown to take place during CTA (Grossman et al., 2008), but the physical connections of the participating neurons are unknown. Using viral injections and confocal fluorescent imaging, we were able to show that excitatory cells involved in CTA project to the Gustatory Cortex. We were also able to show learning dependent Amygdalar projections to novel regions of the brain, including the Lateral Septum (LS) and the Ventromedial Hypothalamus (VMH).
dc.description.sponsorship Brandeis University, Graduate School of Arts and Sciences
dc.format.mimetype application/pdf
dc.language English
dc.language.iso eng
dc.publisher Brandeis University
dc.relation.ispartofseries Brandeis University Theses and Dissertations
dc.rights Copyright by Ramin Ali Marandi Ghoddousi 2017
dc.subject Conditioned Taste Aversion
dc.subject Projections
dc.subject Active Projections
dc.subject FOS
dc.subject NPTX2
dc.subject Learning
dc.subject Memory
dc.subject Neural Circuit
dc.subject Neural Network
dc.title The Active Circuit Involved in Murine Taste Learning
dc.type Thesis
dc.contributor.department Graduate Program in Molecular and Cell Biology MS Masters Molecular and Cell Biology Brandeis University, Graduate School of Arts and Sciences
dc.description.esploro yes

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