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Studies toward the Synthesis of Neu5Acα-(2-6)-Galβ-(1-4)-GlcNAc Trisaccharide

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title Studies toward the Synthesis of Neu5Acα-(2-6)-Galβ-(1-4)-GlcNAc Trisaccharide
contributor.advisor Krauss, Isaac
contributor.author Avery, Keri
contributor.department Department of Chemistry
description.abstract Neu5Acα-(2-6)-Galβ-(1-4)-GlcNAc trisaccharide has been shown to be a known sialic acid glycan linkage. The synthesis towards Neu5Acα-(2-6)-Galβ-(1-4)-GlcNAc trisaccharide involved using acetylation, deacetylation, benzylidenation, debenzylidenation, Koenigs-Knor glycosylation, Schmidt glycosylation, and sialylation reactions. The Galβ-(1-4)-GlcNAc disaccharide was successfully synthesized and will be employed in the studies towards the synthesis of Neu5Acα-(2-6)-Galβ-(1-4)-GlcNAc trisaccharide.
description.sponsorship Brandeis University, Graduate School of Arts and Sciences
identifier.uri http://hdl.handle.net/10192/99
date.issued 2012-08-31
rights Copyright by Keri Avery 2012

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