Rem2 Effects on the Development of Neonatal Mouse Barrel Cortex

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dc.contributor.advisor Stephen, Van Hooser Zhang, Tianyun 2019-02-20T15:45:22Z 2019-02-20T15:45:22Z 2019
dc.description.abstract Rem2 is a small Ras-like GTPase of the Rad/Rem/Rem2/Gem/Kir (RGK) family that is highly expressed in the central nervous system. Previous studies about Rem2 were conducted either in cultured neurons or in the visual system, while we applied Rem2 knockout on the barrel cortices of unilaterally sensory-deprived pups to see its effects on dendritic formation and arborization. We discovered that the loss of Rem2 has resulted in decreases in both the quantity of primary neurites and the sizes of sensory-deprived cells, which was against the normal patterns of sensory deprivation model of the barrel cortex. This phenomenon suggests that Rem2 might play a crucial role specifically on the developmental regulation of deprived barrel cortex layer IV cells, and the underlying mechanisms might differ from those of other neuronal systems.
dc.format.mimetype application/pdf
dc.language English
dc.language.iso eng
dc.publisher Brandeis University
dc.relation.ispartofseries Brandeis University Theses and Dissertations
dc.rights Copyright by Tianyun Zhang 2019
dc.subject Rem2
dc.subject barrel cortex
dc.subject sensory deprivation
dc.subject neuronal development
dc.title Rem2 Effects on the Development of Neonatal Mouse Barrel Cortex
dc.type Thesis
dc.contributor.department Interdepartmental Program in Neuroscience MS Masters Neuroscience Brandeis University, Graduate School of Arts and Sciences

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