Dendritic trafficking faces physiologically critical speed-precision tradeoffs.

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dc.contributor.author Williams, Alex H
dc.contributor.author O'Donnell, Cian
dc.contributor.author Sejnowski, Terrence J
dc.contributor.author O'Leary, Timothy
dc.date.accessioned 2019-01-29T18:18:33Z
dc.date.available 2019-01-29T18:18:33Z
dc.date.issued 2016
dc.identifier.issn 2050-084X
dc.identifier.other PMC5201421
dc.identifier.uri https://hdl.handle.net/10192/36415
dc.description.abstract Nervous system function requires intracellular transport of channels, receptors, mRNAs, and other cargo throughout complex neuronal morphologies. Local signals such as synaptic input can regulate cargo trafficking, motivating the leading conceptual model of neuron-wide transport, sometimes called the 'sushi-belt model' (Doyle and Kiebler, 2011). Current theories and experiments are based on this model, yet its predictions are not rigorously understood. We formalized the sushi belt model mathematically, and show that it can achieve arbitrarily complex spatial distributions of cargo in reconstructed morphologies. However, the model also predicts an unavoidable, morphology dependent tradeoff between speed, precision and metabolic efficiency of cargo transport. With experimental estimates of trafficking kinetics, the model predicts delays of many hours or days for modestly accurate and efficient cargo delivery throughout a dendritic tree. These findings challenge current understanding of the efficacy of nucleus-to-synapse trafficking and may explain the prevalence of local biosynthesis in neurons.
dc.format.extent 1 file
dc.language English
dc.language.iso eng
dc.publisher eLife Sciences Publications Ltd.
dc.relation.isversionof https://dx.doi.org/10.7554/eLife.20556
dc.rights Creative Commons Attribution 4.0 International License
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject active transport
dc.subject computational biology
dc.subject morphology
dc.subject motor proteins
dc.subject neuroscience
dc.subject none
dc.subject plasticity
dc.subject regulation
dc.subject systems biology
dc.subject tagging hypothesis
dc.subject Animals
dc.subject Biological Transport
dc.subject Computer Simulation
dc.subject Humans
dc.subject Kinetics
dc.subject Nerve Net
dc.subject Neural Networks (Computer)
dc.subject Neurons
dc.subject Protein Biosynthesis
dc.subject Synapses
dc.title Dendritic trafficking faces physiologically critical speed-precision tradeoffs.
dc.type Article
dc.contributor.department Department of Biology
dc.relation.journal eLife
dc.identifier.pmid 28034367


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