Two alternating motor programs drive navigation in Drosophila larva.

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dc.contributor.author Lahiri, Subhaneil
dc.contributor.author Shen, Konlin
dc.contributor.author Klein, Mason
dc.contributor.author Tang, Anji
dc.contributor.author Kane, Elizabeth
dc.contributor.author Gershow, Marc
dc.contributor.author Garrity, Paul
dc.contributor.author Samuel, Aravinthan D T
dc.date.accessioned 2019-01-29T18:18:31Z
dc.date.available 2019-01-29T18:18:31Z
dc.date.issued 2011
dc.identifier.issn 1932-6203
dc.identifier.other PMC3156121
dc.identifier.uri https://hdl.handle.net/10192/36405
dc.description.abstract When placed on a temperature gradient, a Drosophila larva navigates away from excessive cold or heat by regulating the size, frequency, and direction of reorientation maneuvers between successive periods of forward movement. Forward movement is driven by peristalsis waves that travel from tail to head. During each reorientation maneuver, the larva pauses and sweeps its head from side to side until it picks a new direction for forward movement. Here, we characterized the motor programs that underlie the initiation, execution, and completion of reorientation maneuvers by measuring body segment dynamics of freely moving larvae with fluorescent muscle fibers as they were exposed to temporal changes in temperature. We find that reorientation maneuvers are characterized by highly stereotyped spatiotemporal patterns of segment dynamics. Reorientation maneuvers are initiated with head sweeping movement driven by asymmetric contraction of a portion of anterior body segments. The larva attains a new direction for forward movement after head sweeping movement by using peristalsis waves that gradually push posterior body segments out of alignment with the tail (i.e., the previous direction of forward movement) into alignment with the head. Thus, reorientation maneuvers during thermotaxis are carried out by two alternating motor programs: (1) peristalsis for driving forward movement and (2) asymmetric contraction of anterior body segments for driving head sweeping movement.
dc.format.extent 1 file
dc.language English
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.isversionof https://dx.doi.org/10.1371/journal.pone.0023180
dc.rights Creative Commons Attribution 4.0 International License
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject Animals
dc.subject Animals, Genetically Modified
dc.subject Drosophila
dc.subject Drosophila Proteins
dc.subject Green Fluorescent Proteins
dc.subject Head Movements
dc.subject Larva
dc.subject Microscopy, Fluorescence
dc.subject Movement
dc.subject Myosin Heavy Chains
dc.subject Orientation
dc.subject Psychomotor Performance
dc.subject Temperature
dc.title Two alternating motor programs drive navigation in Drosophila larva.
dc.type Article
dc.contributor.department Department of Biology
dc.relation.journal PloS One
dc.identifier.pmid 21858019


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