Insight of the cytotoxicity of the aggregates of peptides or aberrant proteins: a meta-analysis.

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dc.contributor.author Zhou, Rong
dc.contributor.author Xu, Bing
dc.date.accessioned 2019-01-28T19:34:21Z
dc.date.available 2019-01-28T19:34:21Z
dc.date.issued 2014
dc.identifier.issn 1932-6203
dc.identifier.other PMC4000214
dc.identifier.uri https://hdl.handle.net/10192/36355
dc.description.abstract Aberrant proteins or peptide aggregates form soluble oligomers or nanofibrils that can cause a wide range of amyloidosis diseases, including Alzheimer's disease (AD). The mechanisms of their cytotoxicity, however, remain controversial and poorly understood, greatly hindering the development of AD drugs. Here we report a comprehensive evaluation of the cytotoxicity of the aggregates by meta-analysis. The analysis indicates that the cytotoxicity of the aggregates converges in a narrower range in the mass concentrations than in the molar concentrations, suggesting that it is the weight of the aggregates rather than the number of the molecules that dictates the cytotoxicity. This new perspective implies that these aggregates are likely to have non-specific interactions with cells to cause cell death. The comparison of several existing theories regarding cellular volumes supports that the aggregates may result in crowding effect and increase the free energy, thus resulting in instability of the cells.
dc.format.extent 1 file
dc.language English
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.isversionof https://dx.doi.org/10.1371/journal.pone.0095759
dc.rights Creative Commons Attribution 4.0 International License
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject Chemistry
dc.subject Protein Structure
dc.subject Molecular Complexes
dc.subject Biochemistry
dc.subject Colloids
dc.subject Research and Analysis Methods
dc.subject Statistical Methods
dc.subject Neurodegenerative Diseases
dc.subject Research Design
dc.subject Mathematics
dc.subject Clinical Research Design
dc.subject Q
dc.subject Movement Disorders
dc.subject Suspensions
dc.subject Materials by Structure
dc.subject R
dc.subject Research Article
dc.subject Biology and Life Sciences
dc.subject Neurology
dc.subject Materials Science
dc.subject Physical Sciences
dc.subject Physical Chemistry
dc.subject Medicine and Health Sciences
dc.subject Protein Interactions
dc.subject Mixtures
dc.title Insight of the cytotoxicity of the aggregates of peptides or aberrant proteins: a meta-analysis.
dc.type Article
dc.contributor.department Department of Chemistry
dc.relation.journal PloS One
dc.identifier.pmid 24769838


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