A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster.

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dc.contributor.author Haynes, Paula R
dc.contributor.author Christmann, Bethany L
dc.contributor.author Griffith, Leslie C
dc.date.accessioned 2019-01-17T19:30:58Z
dc.date.available 2019-01-17T19:30:58Z
dc.date.issued 2015
dc.identifier.issn 2050-084X
dc.identifier.other PMC4305081
dc.identifier.uri https://hdl.handle.net/10192/36132
dc.description.abstract Sleep promotes memory consolidation in humans and many other species, but the physiological and anatomical relationships between sleep and memory remain unclear. Here, we show the dorsal paired medial (DPM) neurons, which are required for memory consolidation in Drosophila, are sleep-promoting inhibitory neurons. DPMs increase sleep via release of GABA onto wake-promoting mushroom body (MB) _'/_' neurons. Functional imaging demonstrates that DPM activation evokes robust increases in chloride in MB neurons, but is unable to cause detectable increases in calcium or cAMP. Downregulation of _'/_' GABAA and GABABR3 receptors results in sleep loss, suggesting these receptors are the sleep-relevant targets of DPM-mediated inhibition. Regulation of sleep by neurons necessary for consolidation suggests that these brain processes may be functionally interrelated via their shared anatomy. These findings have important implications for the mechanistic relationship between sleep and memory consolidation, arguing for a significant role of inhibitory neurotransmission in regulating these processes.
dc.format.extent 1 file
dc.language English
dc.language.iso eng
dc.publisher eLife Sciences Publications Ltd.
dc.relation.isversionof https://dx.doi.org/10.7554/eLife.03868
dc.rights Creative Commons Attribution 4.0 International License
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject D. melanogaster
dc.subject circuits
dc.subject learning and memory
dc.subject neuroscience
dc.subject sleep
dc.subject Acetylcholine
dc.subject Animals
dc.subject Dopamine
dc.subject Drosophila Proteins
dc.subject Drosophila melanogaster
dc.subject Memory
dc.subject Motor Activity
dc.subject Mushroom Bodies
dc.subject Neural Inhibition
dc.subject Neurons
dc.subject Serotonin
dc.subject Sleep
dc.subject Synapses
dc.title A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster.
dc.type Article
dc.contributor.department Department of Biology
dc.relation.journal eLife
dc.identifier.pmid 25564731

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