Convergence of pontine and proprioceptive streams onto multimodal cerebellar granule cells.

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dc.contributor.author Huang, Cheng-Chiu
dc.contributor.author Sugino, Ken
dc.contributor.author Shima, Yasuyuki
dc.contributor.author Guo, Caiying
dc.contributor.author Bai, Suxia
dc.contributor.author Mensh, Brett D
dc.contributor.author Nelson, Sacha B
dc.contributor.author Hantman, Adam W
dc.date.accessioned 2019-01-17T19:30:55Z
dc.date.available 2019-01-17T19:30:55Z
dc.date.issued 2013
dc.identifier.issn 2050-084X
dc.identifier.other PMC3582988
dc.identifier.uri https://hdl.handle.net/10192/36117
dc.description.abstract Cerebellar granule cells constitute the majority of neurons in the brain and are the primary conveyors of sensory and motor-related mossy fiber information to Purkinje cells. The functional capability of the cerebellum hinges on whether individual granule cells receive mossy fiber inputs from multiple precerebellar nuclei or are instead unimodal; this distinction is unresolved. Using cell-type-specific projection mapping with synaptic resolution, we observed the convergence of separate sensory (upper body proprioceptive) and basilar pontine pathways onto individual granule cells and mapped this convergence across cerebellar cortex. These findings inform the long-standing debate about the multimodality of mammalian granule cells and substantiate their associative capacity predicted in the Marr-Albus theory of cerebellar function. We also provide evidence that the convergent basilar pontine pathways carry corollary discharges from upper body motor cortical areas. Such merging of related corollary and sensory streams is a critical component of circuit models of predictive motor control. DOI:http://dx.doi.org/10.7554/eLife.00400.001.
dc.format.extent 1 file
dc.language English
dc.language.iso eng
dc.publisher eLife Sciences Publications Ltd.
dc.relation.isversionof https://dx.doi.org/10.7554/eLife.00400
dc.rights Creative Commons Attribution 3.0 Unported
dc.rights.uri http://creativecommons.org/licenses/by/3.0/
dc.subject Mouse
dc.subject cerebellum
dc.subject corollary discharge
dc.subject proprioception
dc.subject Animals
dc.subject Cerebellum
dc.subject Feedback, Sensory
dc.subject Mice, Inbred C57BL
dc.subject Mice, Transgenic
dc.subject Motor Activity
dc.subject Nerve Fibers
dc.subject Neural Pathways
dc.subject Neuroanatomical Tract-Tracing Techniques
dc.subject Neurons
dc.subject Pons
dc.subject Proprioception
dc.subject Synaptic Transmission
dc.title Convergence of pontine and proprioceptive streams onto multimodal cerebellar granule cells.
dc.type Article
dc.contributor.department Department of Biology
dc.relation.journal eLife
dc.identifier.pmid 23467508


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