Correction: Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling.

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dc.contributor.author Neal, Scott J
dc.contributor.author Takeishi, Asuka
dc.contributor.author O'Donnell, Michael P
dc.contributor.author Park, JiSoo
dc.contributor.author Hong, Myeongjin
dc.contributor.author Butcher, Rebecca A
dc.contributor.author Kim, Kyuhyung
dc.contributor.author Sengupta, Piali
dc.date.accessioned 2019-01-17T19:30:54Z
dc.date.available 2019-01-17T19:30:54Z
dc.date.issued 2015
dc.identifier.issn 2050-084X
dc.identifier.uri https://hdl.handle.net/10192/36110
dc.description.abstract Information about nutrient availability is assessed via largely unknown mechanisms to drive developmental decisions, including the choice of Caenorhabditis elegans larvae to enter into the reproductive cycle or the dauer stage. In this study, we show that CMK-1 CaMKI regulates the dauer decision as a function of feeding state. CMK-1 acts cell-autonomously in the ASI, and non cell-autonomously in the AWC, sensory neurons to regulate expression of the growth promoting daf-7 TGF-_ and daf-28 insulin-like peptide (ILP) genes, respectively. Feeding state regulates dynamic subcellular localization of CMK-1, and CMK-1-dependent expression of anti-dauer ILP genes, in AWC. A food-regulated balance between anti-dauer ILP signals from AWC and pro-dauer signals regulates neuroendocrine signaling and dauer entry; disruption of this balance in cmk-1 mutants drives inappropriate dauer formation under well-fed conditions. These results identify mechanisms by which nutrient information is integrated in a small neuronal network to modulate neuroendocrine signaling and developmental plasticity.
dc.format.extent 1 file
dc.language English
dc.language.iso eng
dc.publisher eLife Sciences Publications Ltd.
dc.relation.isversionof https://dx.doi.org/10.7554/eLife.10110
dc.rights Creative Commons Attribution 4.0 International License
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject C. elegans
dc.subject CaMKI
dc.subject dauer
dc.subject developmental biology
dc.subject neuroendocrine
dc.subject neuroscience
dc.subject stem cells
dc.subject Animals
dc.subject Caenorhabditis elegans
dc.subject Caenorhabditis elegans Proteins
dc.subject Calcium-Calmodulin-Dependent Protein Kinase Type 1
dc.subject Gene Expression Regulation, Developmental
dc.subject Insulins
dc.subject Receptor, Insulin
dc.subject Sensory Receptor Cells
dc.subject Signal Transduction
dc.subject Transforming Growth Factor beta
dc.subject Caenorhabditis elegans Proteins
dc.subject Insulins
dc.title Correction: Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling.
dc.type Article
dc.contributor.department Department of Biology
dc.relation.journal eLife
dc.identifier.pmid 26335407
dc.identifier.pmcid PMC4558564
dc.description.esploro yes


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