Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits

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dc.contributor.author Moore, Anna R.
dc.contributor.author Richards, Sarah E.
dc.contributor.author Kenny, Katelyn
dc.contributor.author Royer, Leandro
dc.contributor.author Chan, Urann
dc.contributor.author Flavahan, Kelly
dc.contributor.author Van Hooser, Stephen D.
dc.contributor.author Paradis, Suzanne
dc.date.accessioned 2018-08-23T19:23:49Z
dc.date.available 2018-08-23T19:23:49Z
dc.date.issued 2018-05-29
dc.identifier.citation eLife 2018;7:e33092 en_US
dc.identifier.issn 2050-084X
dc.identifier.uri https://hdl.handle.net/10192/35872
dc.description The published version can be found on eLife's site: https://elifesciences.org/articles/33092 en_US
dc.description.abstract Sensory experience plays an important role in shaping neural circuitry by affecting the synaptic connectivity and intrinsic properties of individual neurons. Identifying the molecular players responsible for converting external stimuli into altered neuronal output remains a crucial step in understanding experience-dependent plasticity and circuit function. Here, we investigate the role of the activity-regulated, non-canonical Ras-like GTPase Rem2 in visual circuit plasticity. We demonstrate that Rem2-/- mice fail to exhibit normal ocular dominance plasticity during the critical period. At the cellular level, our data establish a cell-autonomous role for Rem2 in regulating intrinsic excitability of layer 2/3 pyramidal neurons, prior to changes in synaptic function. Consistent with these findings, both in vitro and in vivo recordings reveal increased spontaneous firing rates in the absence of Rem2. Taken together, our data demonstrate that Rem2 is a key molecule that regulates neuronal excitability and circuit function in the context of changing sensory experience. en_US
dc.description.sponsorship Supported by National Eye Institute (EY022122), National Institute of Mental Health (K01MH101639), National Institute of Neurological Disorders and Stroke (R01NS065856), National Institute of Neurological Disorders and Stroke (Ruth L Kirschstein NIH Training Grant T32NS007292) and the Charles Hood Foundation. Funded by the Brandeis Open Access Fund. en_US
dc.language.iso en en_US
dc.publisher eLife Sciences Publications en_US
dc.rights Copyright by authors 2018 en_US
dc.subject Neural circuitry en_US
dc.subject Neurons en_US
dc.subject Rem2 en_US
dc.subject Sensory experience en_US
dc.title Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits en_US
dc.type Article en_US
dc.identifier.doi https://doi.org/10.7554/eLife.33092.001 en_US


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