Replacing Carbohydrate with Fat deters the onset and progression of Type II Diabetes Mellitus in male Nile rats

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dc.contributor.advisor Hayes, Kenneth en_US Park, Bumjoon 2017-05-15T16:27:27Z 2017-05-15T16:27:27Z 2017 en_US
dc.description.abstract Since the past couple decades, there has been rising concerns about the increase in incidence of Type II Diabetes Mellitus worldwide. However, there has been contradictory evidence regarding how the macronutrients in the diet, such as carbohydrates, fats and proteins, and the quality of the food especially fat, such as the type of fat saturation, affects the onset of diabetes. In order to investigate the relationship between different gradients of carbohydrate and fat, the fat qualities, and the incidence and severity of diabetes in Nile rats, two studies were designed to feed weanling male Nile rats five different diets with graded carbohydrate:fat ratios while keeping protein constant at 20% energy (70:10:20, 60:20:20, 50:30:20, 40:40:20, and 20:60:20 for CHO:fat:PROT). To assess the onset and progression of T2DM, data from body weight, random blood glucose, fasting blood glucose, the oral glucose tolerance test, food intake, water intake and necropsy were collected and analyzed during a 10 week treatment period of 150 male Nile rats. The results indicate that replacing simple CHO with fat reduces T2DM, whereas the type of fat saturation only had minimal effects by comparison. To conclude, simple CHO is the underlying cause of diabetes in Nile rats, and there is a strong genetic component to this tendency. Further work must be conducted to determine which genes regulate this phenomenon. en_US
dc.format.mimetype application/pdf en_US
dc.language English en_US
dc.language.iso eng en_US
dc.publisher Brandeis University en_US
dc.rights Copyright by Bumjoon Park 2017 en_US
dc.title Replacing Carbohydrate with Fat deters the onset and progression of Type II Diabetes Mellitus in male Nile rats en_US
dc.type Thesis en_US
dc.contributor.department Undergraduate Program in Biology en_US BS en_US Bachelors en_US Biology en_US Brandeis University, College of Arts and Sciences en_US

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