Failure to reproduce reversal of hippocampal LTP by the PKCinhibitor, ZIP

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dc.contributor.advisor Lisman, John en_US
dc.contributor.author Schur, Solon
dc.date.accessioned 2014-10-03T16:36:45Z
dc.date.available 2014-10-03T16:36:45Z
dc.date.issued 2010 en_US
dc.identifier.uri http://hdl.handle.net/10192/28792
dc.description.abstract At the cellular level, some patterns of excitation of neurons have been found to induce long-term increases in synaptic strength between neurons, tlu·ough a process termed long-tem1 potentiation (L TP). While the mechanism of LTP induction is well understood, the mechanisms that lead to the maintenance of synaptic strengthening are not as well understood. PKM( is an isoform of the PKC superfamily and is claimed to be necessary for late-phase LTP maintenance. The main evidence for the role of PKM1; was inferred from reports that L TP can be reduced by the myristoylated 1; -pseudosubstrate peptide (ZTP), claimed to inhibit PKq spccii1cally. Our objectives in this study were to produce stable L TP recordings for up to three hours after induction in an open chamber. This allowed us to test whether we could reproduce ZIP-induced L TP reversal. Measurements were made in the rat CA I region of the hippocampus, as measured by Held recordings. Our experiments have shown that we have successfully induced late phase long-term potentiation in the stratum radiatum of the. CA I region in the hippocampus. However, we were not been able to produce L TP reversal by adding ZIP one hour after LTP induction. We can therefore conclude that furth!!r research should focus on ZIP specificity and the reproducibility of ZIP induced L TP reversal. en_US
dc.format.mimetype application/pdf en_US
dc.language English en_US
dc.language.iso eng en_US
dc.publisher Brandeis University en_US
dc.rights Copyright Solon Schur 2010 en_US
dc.title Failure to reproduce reversal of hippocampal LTP by the PKCinhibitor, ZIP en_US
dc.type Thesis en_US
dc.contributor.department Undergraduate Program in Biology en_US
dc.degree.name BS en_US
dc.degree.level Bachelors en_US
dc.degree.discipline Biology en_US
dc.degree.grantor Brandeis University, College of Arts and Sciences en_US


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