Dicer knockout affects expression of vGluT1 in type Ia afferents

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dc.contributor.advisor Nelson, Sacha
dc.contributor.author Ferrer Socorro, Monica
dc.date.accessioned 2014-05-12T18:19:18Z
dc.date.available 2016-05-09T08:15:24Z
dc.date.issued 2014
dc.identifier.uri http://hdl.handle.net/10192/26997
dc.description.abstract Type Ia sensory neurons are critical for proprioception and are responsible for encoding muscle stretch and providing feedback from muscle to the central nervous system. Although the role of different transcription factors and guiding signals has been studied in the development of the proprioceptive afferents and the spindles they innervate, little is known about how this system is post-transcriptionally regulated. In this study we identify a crucial role of microRNA(s) in the locomotor behavior of mice. Conditional ablation of Dicer through a parvalbumin driven Cre leads to severe ataxia, uncoordinated gait, and hyperextended limbs in mice. Normal morphology in type Ia afferents and muscle spindle innervation is seen, but spindle-associated sensory endings have an almost complete absence of vGluT1 in the tibialis anterior muscle of knockout animals. These findings place Dicer in the pathway for the maintenance of the proprioceptive circuit.
dc.format.mimetype application/pdf
dc.language English
dc.language.iso eng
dc.publisher Brandeis University
dc.relation.ispartofseries Brandeis University Theses and Dissertations
dc.rights Copyright by Monica Ferrer Socorro 2014
dc.title Dicer knockout affects expression of vGluT1 in type Ia afferents
dc.type Thesis
dc.contributor.department Undergraduate Program in Biology
dc.description.embargo 2016-05-09
dc.degree.name BS
dc.degree.level Bachelors
dc.degree.discipline Biology
dc.degree.grantor Brandeis University, College of Arts and Sciences

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