Synthesis of Multivalent Ligands Designed to Inhibit the Tat-TAR Interaction in HIV-1.

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dc.contributor.advisor Pontrello, Jason Schmidt, Minna Y. 2013-06-03T18:23:06Z 2015-05-19T08:15:25Z 2013
dc.description.abstract HIV-1 is currently an incurable disease due to its different strains and high mutation rate [1,10]. Research has shown that the Tat-TAR interaction, which is responsible for the initiation and efficiency of the HIV-1 replication cycle, is a highly conserved interaction among various strains [4]. This interaction is mainly electrostatic and occurs between the positive Tat peptide ARM sequence, a highly basic structure, and the negatively charged backbone of the TAR RNA [12-14]. Certain synthetic molecules containing sulfonate functionalities have been shown to effectively mimic the negative charge on the TAR RNA backbone and bind to the nascent Tat peptide, thus interfering with the Tat-TAR interaction [4]. The following research proposes the synthesis of inhibitory molecules from multivalent polymers with varying ligand type, polymer length, and ligand density that mimic the TAR RNA and which can potentially be used to inhibit that Tat-TAR interaction.
dc.format.mimetype application/pdf
dc.language English
dc.language.iso eng
dc.publisher Brandeis University
dc.relation.ispartofseries Brandeis University Theses and Dissertations
dc.rights Copyright by Minna Y. Schmidt 2013
dc.title Synthesis of Multivalent Ligands Designed to Inhibit the Tat-TAR Interaction in HIV-1.
dc.type Thesis
dc.contributor.department Department of Chemistry
dc.description.embargo 2015-05-19 BS Bachelors Chemistry Brandeis University, College of Arts and Sciences

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