Nicotine as a Neuromodulator of the Gastric-Mill Rhythm

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dc.contributor.advisor Marder, Eve en_US Yang, Roger 2013-05-30T19:45:46Z 2013-05-30T19:45:46Z 2013 en_US
dc.description.abstract Neuromodulators can have long-lasting effects on neural circuits by changing the intrinsic membrane properties of neurons as well as the synaptic connections between them. Over recent years, many neuromodulatory substances have been identified in the stomatogastric ganglion (STG) of different crustacean species. The majority of them are now known to be released onto the STG as either descending or ascending inputs from projection neurons, and some have been shown to circulate as hormones. One neurotransmitter agonist that has not been characterized thoroughly in the STG is nicotine. Previous studies have found however, that some neurons in the STG do exhibit nicotinic-like responses when their receptors are bound by other cholinergic agonists. Considering that nicotine’s modulatory actions are mostly unknown, the exogenous application of nicotine to the STG can be an insightful method for the detection of large-scale changes to motor rhythm output. Results from nicotine-application experiments show that nicotine can activate or terminate the gastric-mill rhythm in Cancer borealis, and increase the rate of action potentials fired by the lateral gastric neuron (LG). Wider implications of nicotine’s effects are that there are nicotinic acetylcholine receptors in the STG network, and that nicotine can be a state-dependent modulator of the gastric-mill rhythm. en_US
dc.format.mimetype application/pdf en_US
dc.language English en_US
dc.language.iso eng en_US
dc.publisher Brandeis University en_US
dc.relation.ispartofseries Brandeis University Theses and Dissertations
dc.rights Copyright by Roger Yang 2013 en_US
dc.title Nicotine as a Neuromodulator of the Gastric-Mill Rhythm en_US
dc.type Thesis en_US
dc.contributor.department Undergraduate Program in Biology en_US BS en_US Bachelors en_US Biology en_US Brandeis University, College of Arts and Sciences en_US

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